Methotrexate

I tried methotrexate, there is plenty of research into its efficiency, for some people it works really well with no side effects and others there are side effects all depends on the person really. For me I took methotrexate for 2 months, didn't note anything different in that time and for 2 days after taking it I had what closely resembles a hangover (fatigue and slight nausea). My dermatologist didn't think it was doing much for me so switched me to cyclosporine. Good look on your journey.

Sorry to hear about your daughter. My psoriasis started when I was 17, and only became severe when I was 26. I can't begin to imagine what it must be like for a child. Between August 2011 and March 2012 I started taking 10mg Methrotrexate and gradually worked up to 20mg, which I think is the maximum. It did not improve my psoriasis at all, which at the time covered my neck to ankles almost entirely. I did experience side effects for a couple of weeks after increasing the dosage to 15mg: aches, shoulder pains, numb/tingling feeling in hands and feet, tiredness, feeling weak, pain in joints and muscles, headache. I then stopped and tried other treatments. Although it didn't work for me, it does work for lots of others. I hope it works for your daughter.