Constantly changing symptoms of PSA

Hi and merry Christmas. I've had psoriasis and now it appears PSA, for many years but the PSA went undiagnosed until last year when symptoms increased dramatically after an operation I had. So far a combined treatment of methotrexate and Leflunomide has not stopped flare ups or improved bad morning stiffness and sharp pains in various joints but mainly the tendon attachments. I am hoping to be moved onto the biologic treatments in the new year. Until recently it was down one side of my body (right hand, ankle and foot right hip and shoulder) it's now starting to show in my left hand fingers Has anyone experienced this and could it mean it's getting worse? Also has anyone experienced an improvement with the switch from Dmards to biologic treatments? Thanks for reading. Paul