Methotrexate

I started on methotrexate in March this year, anlso after a severe flareup in psoriasis last winter. I’m not sure whether this was Covid related, as I’ve never actually had Covid, but obviously there could be some relationship to vaccinations, I simply don’t know. Admittedly I’m on a higher dose than you (15 mg weekly), however, I would say that I began to notice a difference probably in 4 to 6 weeks. I had previously been on acitretin for many many years. On the whole, I would say that methotrexate is a better solution - initially, it cleared the severe flare up very quickly – but now it’s about 85 to 90% effective and I still need to use enstilar foam quite a bit Hope that helps you

Thanks for the question and answer on Methotrexate. I've just been prescribed 15 mg weekly and wondering what to expect from side effects. Other than a few spots on my legs, my hands and feet have about placed me on disability status. Ive tried 4 different steroids; however, each ate through layers of skin. So effective or not, I couldn't continue on the steroids. Supposedly these are my "golden years", but I beg to differ! Lol ...

Methotrexate has a rap sheet about a mile long, so it’s difficult to be precise in side effects. The main ones I’ve experienced have been a bit of ‘digestive turbulence’ some days, and I think an effect on blood glucose (I’m also a type 2 diabetic) which in my brain has resulted in a couple of kilos weight gain. This isn’t on the sheet as a side effect but to me the effect seemed pretty immediate. It’s an irritation more than anything else as I had been steadily losing weight which now seems to have stopped. Heigh ho….